Journal: OTO Open

Article Title: Multicancer Early Detection Tests: A State‐of‐the‐Art Review for Otolaryngologists

doi: 10.1002/oto2.70040

Figure Lengend Snippet: Ongoing or Upcoming Clinical Trials Related to Multi‐Cancer Early Detection Tests

Article Snippet: NCT05431621 Case‐control , N/A , Establishment of Molecular Classification Models for Early Diagnosis of Digestive System Cancers , China , (Singlera Genomics) , Methylation, fragmentomics, miRNA markers, circulating tumor cells (blood) , 2023.

Techniques: Clinical Proteomics, Biomarker Discovery, Methylation, Diagnostic Assay, DNA Methylation Assay, Sequencing, Control

Journal: Diagnostics

Article Title: Analytical Validation of Esopredict, an Epigenetic Prognostic Assay for Patients with Barrett’s Esophagus

doi: 10.3390/diagnostics14182003

Figure Lengend Snippet: Normalized methylation values (NMV) for each gene at the LOB and LOD.

Article Snippet: In background studies performed at Johns Hopkins University and validation studies at Previse, four specific methylation markers ( p16 , RUNX3 , HPP1 , and FBN1 ) have demonstrated consistent statistically significant performance as early harbingers of neoplastic progression in BE, presenting an opportunity for improved prognostication in BE patients [ , , , ].

Techniques: Methylation

Journal: Diagnostics

Article Title: Analytical Validation of Esopredict, an Epigenetic Prognostic Assay for Patients with Barrett’s Esophagus

doi: 10.3390/diagnostics14182003

Figure Lengend Snippet: Normalized methylation values (NMV) for each gene and tissue sample.

Article Snippet: In background studies performed at Johns Hopkins University and validation studies at Previse, four specific methylation markers ( p16 , RUNX3 , HPP1 , and FBN1 ) have demonstrated consistent statistically significant performance as early harbingers of neoplastic progression in BE, presenting an opportunity for improved prognostication in BE patients [ , , , ].

Techniques: Methylation

Journal: Diagnostics

Article Title: Analytical Validation of Esopredict, an Epigenetic Prognostic Assay for Patients with Barrett’s Esophagus

doi: 10.3390/diagnostics14182003

Figure Lengend Snippet: Transformed normalized methylation values for each gene and tissue sample.

Article Snippet: In background studies performed at Johns Hopkins University and validation studies at Previse, four specific methylation markers ( p16 , RUNX3 , HPP1 , and FBN1 ) have demonstrated consistent statistically significant performance as early harbingers of neoplastic progression in BE, presenting an opportunity for improved prognostication in BE patients [ , , , ].

Techniques: Transformation Assay, Methylation

Journal: Diagnostics

Article Title: Analytical Validation of Esopredict, an Epigenetic Prognostic Assay for Patients with Barrett’s Esophagus

doi: 10.3390/diagnostics14182003

Figure Lengend Snippet: Primers and probes for quantitative PCR. Probes are dual-labeled with FAM and quencher.

Article Snippet: In background studies performed at Johns Hopkins University and validation studies at Previse, four specific methylation markers ( p16 , RUNX3 , HPP1 , and FBN1 ) have demonstrated consistent statistically significant performance as early harbingers of neoplastic progression in BE, presenting an opportunity for improved prognostication in BE patients [ , , , ].

Techniques: Real-time Polymerase Chain Reaction, Sequencing